In this systematic review. the antimicrobial effect of ion-substituted calcium phosphate biomaterials was quantitatively assessed. The literature was systematically searched up to the 6th of December 2021. Study selection and data extraction was performed in duplo by two independent reviewers with a modified version of the OHAT tool for risk of bias assessment. https://www.spidertattooz.com/The-GelBottle-Inc-BIAB-Gel-Polish-Spirited-67oz-p17706/