Background: Cleidocranial dysplasia (CCD) is a rare. autosomal dominant skeletal dysplasia with a prevalence of one per million births. The main causes of CCD are mutations in the core-binding factor alpha-1 (CBFA1) or runt-related transcription factor-2 (RUNX2). located at the 6p21 chromosomal region. https://parisnaturalfoodes.shop/product-category/canadian-pine-bark-extract/